Thermo Fisher Scientific DRAM Polyclonal Antibody
DRAM 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. Human, Mouse, Rat에 반응하며, 합성 펩타이드(aa 160-210)를 면역원으로 사용했습니다. 동결건조 형태로 제공되며, 연구용으로만 사용 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DRAM Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 160–210 of human DRAM conjugated to blue carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen shares 85% identity with mouse and rat.
- Specificity of this antibody: DRAM.
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles.
Activation of DRAM by p53 occurs alongside activation of proapoptotic genes such as PUMA and Bax, together promoting a full cell death response.
Although DRAM alone cannot induce apoptosis, its inactivation in certain cancers underscores its importance and suggests autophagy may play a more significant role in cancer than previously thought.
At least two different isoforms of DRAM are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.