Thermo Fisher Scientific DRAM Polyclonal Antibody
DRAM 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF 등에 사용 가능. 합성 펩타이드(aa 160–210) 기반 항원으로 제작되었으며, 1 mg/mL 농도의 동결건조 형태. 연구용으로만 사용하며 p53 관련 자가포식 연구에 적합.
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Thermo Fisher Scientific DRAM Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | - |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 160–210 of human DRAM conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985254 |
Product Specific Information
- Reconstitute with 500 µL of distilled water.
- The antigen shares 85% identity with mouse and rat DRAM sequences.
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs alongside activation of proapoptotic genes such as PUMA and Bax, collectively promoting full cell death responses.
DRAM alone cannot induce apoptosis, but its inactivation in certain cancers highlights its importance and suggests that autophagy may play a more significant role in cancer progression than previously thought.
At least two different isoforms of DRAM are known.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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