Thermo Fisher Scientific DRAM Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Miscellaneous PubMed (Misc)

• Publications: View 2 publications

Product Specifications

Product Specific Information

• Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
• The antigen shares 85% identity with mouse and rat.
• Specificity: DRAM.

Target Information

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 may occur simultaneously with activation of proapoptotic genes such as PUMA and Bax, promoting a full cell death response. DRAM itself cannot induce apoptosis, but its inactivation in certain cancers suggests autophagy may play a significant role in cancer progression. At least two isoforms of DRAM are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.