Thermo Fisher Scientific CD46 Monoclonal Antibody (MEM-258), PE
PE 형광으로 표지된 CD46 단클론 항체로 인간 및 소 반응성. Flow Cytometry에 적합하며, 세포 표면 CD46 단백질 검출에 사용. 액상 형태로 제공되며, 4°C 암소 보관. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 20 µL x 100 µL whole blood or 10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-258 |
| Immunogen | T cell line HPB-ALL |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072492 |
Additional Formats
- Unconjugated
- Alexa Fluor 700
- APC
- Biotin
- FITC
- Request custom conjugation available
Product Specific Information
This antibody recognizes an extracellular epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein).
CD46 is a 56–66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells, and fibroblasts; it is negative on erythrocytes.
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments.
It regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction.
CD46 also serves as a receptor for several human pathogens and modulates T lymphocyte polarization toward antigen-presenting or target cells, inhibiting lymphocyte function.
Additionally, CD46 protects placental tissue and is expressed on the inner acrosomal membrane of spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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