Thermo Fisher Scientific CD46 Monoclonal Antibody (MEM-258), PE

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 20 µL x 100 µL whole blood or 10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 700
• APC
• Biotin
• FITC
• Request custom conjugation available

Product Specific Information

This antibody recognizes an extracellular epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein).
CD46 is a 56–66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells, and fibroblasts; it is negative on erythrocytes.

Target Information

CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments.
It regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction.
CD46 also serves as a receptor for several human pathogens and modulates T lymphocyte polarization toward antigen-presenting or target cells, inhibiting lymphocyte function.
Additionally, CD46 protects placental tissue and is expressed on the inner acrosomal membrane of spermatozoa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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