Thermo Fisher Scientific CD41 Monoclonal Antibody (MEM-06), PE
CD41(GPIIb) 항원을 인식하는 마우스 단일클론 항체로, PE 형광체가 결합되어 있습니다. 인간 유래 시료에 반응하며 주로 혈소판 및 거핵세포 표지에 사용됩니다. 유세포분석(Flow Cytometry)에 적합하며, 액상 형태로 4°C 암소 보관합니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-06 |
| Immunogen | Leucocytes from a patient suffering from a LGL type leukaemia |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075441 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- Biotin
- FITC
- PerCP
- Custom conjugation available
Product Specific Information
This antibody reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains: GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits—120 kDa alpha and 23 kDa beta—that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is involved in blood coagulation by mediating platelet aggregation. Upon vascular injury, CD41 binds to proteins such as von Willebrand factor, fibrinogen, fibronectin, and vitronectin. It is primarily expressed in the megakaryocyte-platelet lineage and during early hematopoietic differentiation.
Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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