Thermo Fisher Scientific CD44 Polyclonal Antibody
CD44 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB, IHC, Flow Cytometry 등에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide RF AGV FHV EKN GRY SIS RTE corresponding to human CD44 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast cancer tissue
- Cellular location: Membrane
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein expressed on human leukocytes, brain white matter, and various epithelial cells. It serves as a receptor for hyaluronic acid (HA) and mediates cell-cell interactions, adhesion, and migration. CD44 plays roles in lymphocyte activation, recirculation, and homing. Expression may be upregulated in carcinomas and associated with metastatic potential. It is found in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 highly, while peripheral B and T cells upregulate CD44 upon stimulation. The gene undergoes complex alternative splicing, producing diverse isoforms. CD44 dysfunction is linked to diseases such as superficial keratitis and lichen sclerosus and may relate to tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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