Thermo Fisher Scientific Trypsin 2 Recombinant Rabbit Monoclonal Antibody (ARC2453)
Recombinant rabbit monoclonal antibody against Trypsin 2 (PRSS2). Validated for WB, IHC, and ELISA. High specificity and sensitivity for human, mouse, and rat samples. Supplied in liquid form with glycerol for stable long-term storage.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2453 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human PRSS2 (UniProt ID: P07478) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897822 |
Product Specific Information
- Positive samples: Mouse pancreas, Rat pancreas
- Immunogen sequence:
MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN
Target Information
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds following lysine or arginine residues. Trypsin 2 is highly expressed in pancreatic juice and upregulated in pancreatitis. It can activate pro-urokinase in ovarian tumors, contributing to tumor invasion, and cleave the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially degrading cartilage matrix. Alternative splicing yields multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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