Thermo Fisher Scientific ACVR1 Recombinant Rabbit Monoclonal Antibody (ARC2449)
ACVR1 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며, HEK293 세포에서 발현된 재조합 항체입니다. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 버퍼에 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2449 |
| Immunogen | A synthetic peptide corresponding to amino acids 410–509 of human ACVR1 (UniProt ID: Q04771) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20 °C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897821 |
Product Specific Information
Positive Samples: 293T, A-549, MCF7, Mouse brain, Rat testis, Rat brain
Immunogen Sequence:
VLWEVARRMV SNGIVEDYKP PFYDVVPNDP SFEDMRKVVC VDQQRPNIPN RWFSDPTLTS LAKLMKECWY QNPSARLTAL RIKKTLTKID NSLDKLKTDC
Target Information
Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-β) superfamily of signaling proteins.
ACVR1 mediates specific transcriptional responses in concert with activin type II receptors.
Mutations in ACVR1 are associated with Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by ectopic bone formation in muscles, tendons, and connective tissues, as well as Epicanthus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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