Thermo Fisher Scientific SDHB Monoclonal Antibody (CL0347)
Human SDHB 단백질을 인식하는 Mouse monoclonal antibody(CL0347). Western blot 및 IHC(Paraffin)에 최적화되어 있음. Protein A로 정제된 액상 항체로, PBS(40% glycerol) buffer에 보존됨. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0347 |
| Immunogen | Recombinant protein corresponding to Human SDHB (amino acids 165–273) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848885 |
Product Specific Information
Immunogen sequence:
EGKQQYLQSI EEREKLDGLY ECILCACCST SCPSYWWNGD KYLGPAVLMQ AYRWMIDSRD DFTEERLAKL QDPFSLYRCH TIMNCTRTCP KGLNPGKAIA EIKKMMATY
Target Information
Complex II of the respiratory chain is involved in the oxidation of succinate and electron transfer from FADH to CoQ. It consists of four nuclear-encoded subunits localized in the mitochondrial inner membrane. The iron-sulfur subunit (SDHB) is highly conserved and contains three cysteine-rich clusters that form the enzyme’s iron-sulfur centers. Mutations in this gene are associated with paragangliomas and pheochromocytoma, linking mitochondrial dysfunction to tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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