Thermo Fisher Scientific CD206 Monoclonal Antibody (CL0387)
Human CD206 단백질에 특이적인 Mouse IgG2b 단클론 항체로, Western blot 및 파라핀 IHC에 적합. Protein A 정제, PBS/glycerol buffer, 4°C 또는 -20°C 보관. 면역 및 대식세포 관련 연구용으로 최적화.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0387 |
| Immunogen | Recombinant protein corresponding to Human CD206 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2848886 |
Product Specific Information
Immunogen sequence:
NEDHKRCVDA VSPSAVQTAA CNQDAESQKF RWVSESQIMS VAFKLCLGVP SKTDWVAITL YACDSKSEFQ KWECKNDTLL GIKGEDLFFN YGNRQEKNIM LYKGSGLWSR WKIYG
Target Information
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors.
It is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells, and sperm cells. CD206 plays an important role in innate and adaptive immune responses.
Also expressed on microglia and mato cells of the brain, but not on astrocytes or neurons.
CD206 mediates the recognition and uptake of various macromolecules, including modified lipoproteins, advanced glycation end products (AGEs), and amyloid β-protein (Aβ).
While its normal role involves cell adhesion and host defense, CD206 has also been implicated in atherosclerosis and amyloid β deposition in Alzheimer’s disease (AD).
The CD206 gene encodes class A macrophage scavenger receptors, which include three isoforms (1, 2, 3) generated by alternative splicing.
- Isoforms 1 and 2: functional receptors mediating endocytosis of modified LDLs.
- Isoform 3: does not internalize modified LDL and remains trapped within the endoplasmic reticulum, exerting a dominant negative effect on isoforms 1 and 2.
CD206 dysfunction has been associated with diseases such as leprosy and Gaucher’s disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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