Thermo Fisher Scientific Metadherin Monoclonal Antibody (CL0397)
인간 Metadherin 단백질을 인식하는 Mouse IgG2a 단일클론 항체입니다. WB, IHC(P), ICC/IF에 사용 가능하며 고순도 Protein A 정제 제품입니다. PBS/glycerol 용액 형태로 제공되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0397 |
| Immunogen | Recombinant protein corresponding to Human Metadherin (UniProt ID: Q86UE4-1, Antigen range: 315–461) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848887 |
Product Specific Information
Immunogen sequence:
RKTEPSAWSQ DTGDANTNGK DWGRSWSDRS IFSGIGSTAE PVSQSTTSDY QWDVSRNQPY IDDEWSGLNG LSSADPNSDW NAPAEEWGNW VDEERASLLK SQEPIPDDQK VSDDDKEKGE GALPTGKSKK KKKKKKKQGE DNSTAQD
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a novel protein localized with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It participates in tight junction maturation rather than serving as a structural component.
Metadherin is overexpressed in breast cancer tissue and xenografts, with lower expression in normal breast tissue. It binds to lung vasculature through a C-terminal extracellular domain segment. Blocking this domain with antibodies or inhibiting Metadherin via siRNA has been reported to suppress breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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