Thermo Fisher Scientific Integrin beta 1 (CD29) Recombinant Rabbit Monoclonal Antibody (SA40-08)
Thermo Fisher의 Integrin beta 1 (CD29) 재조합 토끼 단클론 항체 SA40-08은 높은 특이성과 민감도를 제공하며, 인간·마우스·랫·제브라피쉬에 반응합니다. WB, IHC(P) 등 다양한 응용에 적합하며, 일관된 로트 간 품질과 동물 유래 성분 없는 제형을 특징으로 합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| in situ PLA (PLA) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SA40-08 |
| Immunogen | Recombinant protein within Human Integrin beta 1 (aa 1–240) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809258 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
ITGB1 (Integrin Subunit Beta 1, CD29)
ITGB1 is a 110 kDa cell surface glycoprotein expressed by various cells including all leukocytes. It forms non-covalent heterodimers with multiple alpha chains (α1–α6, CDa–f), determining beta1 (VLA) integrin binding properties.
Key Functional Insights:
- Acts as a cell adhesion molecule on platelets and leukocytes
- Involved in immune cell trafficking and tissue migration
- Correlates with multidrug resistance in tumor cells
- Plays roles in inflammatory bowel disease and cytokine regulation
- Exists in two major isoforms: β1A and β1D, with tissue-specific distribution
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-31964_Integrin_beta_1_CD29_P05556-1_Rabbit.svg, MA5-31964_Integrin_beta_1_CD29_P05556-1_Rabbit_PDP.jpeg)
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