Thermo Fisher Scientific Cyclin E Recombinant Rabbit Monoclonal Antibody (9H12)

Applications and Tested Dilution

Product Specifications

Target Information

Cyclin E belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.

Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability and may contribute to tumorigenesis.

This protein is associated with the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants encoding distinct isoforms have been described. Two additional splice variants have been reported but detailed nucleotide sequence information is not yet available.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.