Thermo Fisher Scientific HnRNP Q Recombinant Rabbit Monoclonal Antibody (9C7)
Human hnRNP Q 단백질을 인식하는 재조합 토끼 모노클론 항체로 다양한 면역학적 실험(IHC, ICC/IF, ELISA)에 적용 가능. 높은 특이성과 재현성을 제공하며, 액상 형태로 제공되어 사용이 편리함. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:20–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9C7 |
| Immunogen | Synthesized peptide derived from human hnRNP Q |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.83 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092635 |
Target Information
Heterogeneous nuclear ribonucleoprotein (hnRNP) Q is implicated in mRNA processing mechanisms. It is a component of the CRD-mediated complex that promotes MYC mRNA stability. Isoforms 1, 2, and 3 are associated with pre-mRNA, splicing intermediates, and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences and is part of the APOB mRNA editosome complex, potentially modulating post-transcriptional C to U RNA editing via interactions with A1CF, APOBEC1, or RNA itself. hnRNP Q may be involved in translationally coupled mRNA turnover and cytoplasmic mRNA decay mechanisms with other RNA-binding proteins. Isoform 3 may participate in cytoplasmic vesicle-based mRNA transport through interactions with synaptotagmins. It is also a component of the GAIT (gamma interferon-activated inhibitor of translation) complex, mediating interferon-gamma-induced transcript-selective translation inhibition during inflammation. Upon activation, the GAIT complex binds to stem-loop GAIT elements in the 3′-UTR of inflammatory mRNAs (e.g., ceruloplasmin) to suppress translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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