Thermo Fisher Scientific ABCG1 Recombinant Rabbit Monoclonal Antibody (SU03-26)
ABCG1 단백질을 검출하기 위한 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며 높은 특이성과 민감도를 제공합니다. HEK293 발현 시스템으로 생산되어 로트 간 일관성과 동물 유래 성분이 없습니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SU03-26 |
| Immunogen | Synthetic peptide within Human ABCG1 aa 161–210 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809403 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
ATP-binding cassette (ABC) transporter genes regulate dietary cholesterol retention.
The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages. It is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein.
Conversely, lipid efflux mediated by HDL(3) suppresses ABCG1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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