Thermo Fisher Scientific DARPP-32 Recombinant Rabbit Monoclonal Antibody (SU0329)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200
• View 1 publication

Flow Cytometry (Flow)

• Tested Dilution: 1:50–1:100

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

DARPP-32 is a dopamine (DA) and AMP-regulated ~32 kDa phosphoprotein associated with dopaminoceptive neurons.

• When phosphorylated on Thr34, it inhibits Protein Phosphatase I.
• When phosphorylated on Thr75, it acts as an inhibitor of PKA.
  Phosphorylation of DARPP-32 plays a critical role in dopaminergic neurotransmission and is implicated in the actions of alcohol, caffeine, and Prozac®.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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