Thermo Fisher Scientific WASP Polyclonal Antibody
WASP 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P) 실험에 적합합니다. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
- 카탈로그번호
- PA578225
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of Human WASP (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736790 |
Product Specific Information
- Positive Control: Raji, NCI-H929
- Predicted Reactivity: Rat (87%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Wiskott-Aldrich syndrome family of proteins share similar domain structure and are involved in signal transduction from cell surface receptors to the actin cytoskeleton. These proteins interact with multiple partners and are regulated by various stimuli. They associate with small GTPase Cdc42 and the Arp2/3 complex, which regulate actin filament formation.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked recessive disease characterized by immune dysregulation and microthrombocytopenia, caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells, showing signaling and cytoskeletal abnormalities in affected patients.
A transcript variant with an alternative promoter and different 5′ UTR sequence has been described, though its full-length nature remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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