Thermo Fisher Scientific ITGB1 Monoclonal Antibody (TS2/16)
Human CD29(ITGB1) 인식 단일클론 항체로 다양한 응용(WB, IHC, Flow, ELISA 등)에 적합. TS2/16 클론, Mouse IgG1 형식. 1 mg/mL 농도, PBS buffer, preservative 없음. 연구용으로 세포 부착 및 면역반응 연구에 활용 가능.
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- MA2910
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Thermo Fisher Scientific ITGB1 Monoclonal Antibody (TS2/16)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 1 publication |
| Immunohistochemistry (IHC) | - | 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | 2 publications |
| ELISA | - | 1 publication |
| Immunoprecipitation (IP) | - | 1 publication |
| Neutralization (Neu) | - | 12 publications |
| Immunomicroscopy (IM) | - | 1 publication |
| Inhibition Assays (IA) | - | 1 publication |
| T-Cell Activation (TCA) | - | 2 publications |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TS2/16 |
| Immunogen | Human Beta1 Integrin, the Beta1 chain of the Beta1 integrin heterodimer (CD29) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_223515 |
Product Specific Information
MA2910 targets CD29 in FACS applications and shows reactivity with Human samples.
The immunogen is human Beta1 Integrin, the Beta1 chain of the Beta1 integrin heterodimer (CD29).
MA2910 detects CD29 with a predicted molecular weight of approximately 88 kDa.
This antibody has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains ≤10 EU/mg endotoxin concentration.
Target Information
ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cells including all leukocytes.
It forms non-covalently linked heterodimers with at least six different alpha chains (α1–α6, CDa–f), determining the binding properties of beta1 (VLA) integrins.
ITGB1 acts as a cell adhesion molecule on platelets and participates in protein complexes binding extracellular matrix proteins.
Decreased expression correlates with multidrug resistance in tumor cells.
It is up-regulated in leukocytes during emigration and migration, regulating immune cell trafficking.
ITGB1 also influences tissue damage and inflammatory bowel disease symptoms.
Through ITGB1-dependent mechanisms, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1β.
Two major forms, beta1A and beta1D, differ by 13 amino acids and exhibit tissue-specific expression patterns.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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