Thermo Fisher Scientific BAP31 Monoclonal Antibody (CC-1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,500-1:6,000

View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

1:1,000-1:10,000

-

Immunocytochemistry (ICC/IF)

1:200-1:1,000

View 8 publications 8 publications

ELISA (ELISA)

Assay-dependent

-

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Bovine, Hamster, Human, Mouse, Non-human primate

Published species

Human, Mouse, Non-human primate

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

CC-1

Immunogen

Amino acid residues 230-246 of BAP31 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BAP31,uniProtId:P51572-1,ncbiNodeId:9606,antigenRange:230-246,antigenLength:246,antigenImageFileName:MA3-002_BAP31_P51572-1_Rat.svg,antigenImageFileNamePDP:MA3-002_BAP31_P51572-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_325095

Product Specific Information

MA3-002 detects BAP31 from human, non-human primate, bovine, mouse and hamster samples.

MA3-002 has been successfully used in Western blot, ELISA, immunoprecipitation, immunofluorescent, and immunohistochemical procedures. By Western blot, this antibody detects a 28-kDa protein corresponding to human BAP31.

The MA3-002 antigen is solubilized protein from human neuroendocrine cell line IMR-32 corresponding to the C-terminal region residues 230-246 of BAP31 protein. This sequence is conserved in non-human primate, bovine and hamster species.

Target Information

BAP31 (B-Cell Receptor Associated Protein, 31-kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo- and hetero-oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL-2/BCL-XL-associated protein. In the C-terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.