Thermo Fisher Scientific BAP31 Monoclonal Antibody (CC-1)

Thermo Fisher Scientific BAP31 Monoclonal Antibody (CC-1)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA3-002 detects BAP31 from human, non-human primate, bovine, mouse, and hamster samples.
It has been successfully used in Western blot, ELISA, immunoprecipitation, immunofluorescent, and immunohistochemical procedures.
By Western blot, this antibody detects a 28-kDa protein corresponding to human BAP31.

The MA3-002 antigen is solubilized protein from human neuroendocrine cell line IMR-32 corresponding to the C-terminal region residues 230–246 of BAP31 protein.
This sequence is conserved in non-human primate, bovine, and hamster species.

Target Information

BAP31 (B-Cell Receptor Associated Protein, 31-kDa) is a multiple membrane-spanning protein of the endoplasmic reticulum.
It forms homo- and hetero-oligomers with BAP29 and acts as a potential apoptotic regulator associated with BCL-2/BCL-XL.
The C-terminal domain contains recognition sites for initiator Caspases 1 and 8, suggesting a role in programmed cell death.
BAP31 is involved in the transport of selected proteins to the Golgi apparatus and regulates CFTR expression.
Alteration of BAP31 function may influence chloride channel regulation in cystic fibrosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.