Thermo Fisher Scientific Phospho-SRC (Tyr419) Polyclonal Antibody
SRC 단백질의 Tyr419 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간, 생쥐, 닭 등 여러 종에 반응하며, Affinity chromatography로 정제된 액상 형태. 세포 신호전달 및 암 연구에 적합.
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Thermo Fisher Scientific Phospho-SRC (Tyr419) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | 59 |
| Immunohistochemistry (IHC) | - | 16 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 |
| Immunocytochemistry (ICC/IF) | - | 14 |
| ELISA | - | 1 |
| Immunoprecipitation (IP) | - | 10 |
| Miscellaneous PubMed (Misc) | - | 9 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human, Mouse |
| Published Species | Bovine, Dog, Fruit fly, Human, Mouse, Pig, Rat, Tag, Xenopus, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from human Src region containing Tyr419. Sequence conserved in mouse, rat, chicken, and frog. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533714 |
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. It associates with various cell surface receptors to facilitate signal transduction and plays roles in cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, SRC is located on chromosome 20. Its activity is regulated by phosphorylation at Tyr416 (activation) and Tyr527 (inhibition). Mutations in SRC may contribute to malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been identified.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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