Thermo Fisher Scientific SRC Polyclonal Antibody
SRC 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot, ICC/IF, IP에 적합합니다. 인간과 생쥐에서 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 세포 성장 및 신호전달 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 8 publications |
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| Immunoprecipitation (IP) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Dog, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized peptide derived from the amino acid region 31–49 of human Src protein. The sequence is conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20 °C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533712 |
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. It regulates growth and differentiation of eukaryotic cells and associates with cytoplasmic regions of various cell surface receptors to facilitate signal transduction. SRC also participates in cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, the SRC gene is located on chromosome 20. Its activity is regulated by two tyrosine residues (Tyr416 and Tyr527), with phosphorylation of Tyr416 activating and Tyr527 inhibiting enzyme activity. Mutations in SRC may contribute to malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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