Thermo Fisher Scientific SRC Polyclonal Antibody
SRC 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), IP에 사용 가능. 인간 및 생쥐 시료에 적합하며, 비결합형 액상 형태로 제공. 세포 신호전달, 성장 및 분화 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from amino acid region 6–19 of human Src. The sequence is conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533711 |
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. It participates in the regulation of growth and differentiation of eukaryotic cells, associating with cytoplasmic regions of various cell surface receptors to facilitate signal transduction. SRC also plays roles in cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, the SRC gene is located on chromosome 20. Its activity is regulated by two tyrosine residues (Tyr416 and Tyr527), whose phosphorylation has opposing effects: phosphorylation of Tyr416 activates the enzyme, while phosphorylation of Tyr527 inhibits it. Mutations in SRC may contribute to malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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