Thermo Fisher Scientific Cyclin E Polyclonal Antibody
Cyclin E 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 적합합니다. Human에 반응하며 Mouse, Rat 등 예측 반응성을 보입니다. 항원 친화 크로마토그래피로 정제된 액상 형태 제품입니다.
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- PA585177
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- pk
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Thermo Fisher Scientific Cyclin E Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human Cyclin E1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792323 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (85%), Rat (85%), Chicken (80%), Bovine (86%).
- Positive Control: U87-MG, MCF-7, MDA-MB-231, HCT-116, HCT-116 (1 mM Hydroxyurea treatment for 24 hr).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cyclin E belongs to the highly conserved cyclin family, characterized by periodic protein abundance through the cell cycle. Cyclins regulate CDK kinases, and Cyclin E forms a complex with CDK2 to control the G1/S transition. It accumulates at the G1-S boundary and is degraded during S phase. Overexpression is associated with chromosomal instability and tumorigenesis. Cyclin E also interacts with NPAT, contributing to histone gene expression and cell-cycle progression. Multiple splice variants have been described.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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