
Thermo Fisher Scientific CRYAB Polyclonal Antibody
CRYAB 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 적합합니다. Human, Mouse, Rat에 반응하며 고순도 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB): 1:5,000–1:50,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human crystallin alpha B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792324 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (97%), Rat (96%), Rabbit (97%), Chicken (81%), Sheep (96%), Rhesus Monkey (99%), Bovine (97%), Guinea pig (97%).
- Positive control: Mouse eye.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest and composed of two primary gene products, alpha-A and alpha-B.
Alpha-Crystallin comprises about 40% of total lens protein composition and functions as a molecular chaperone, preventing protein aggregation that may lead to cataract formation.
Phosphorylated states of alpha-crystallin may respond to cellular stress and play a role in structural control and protein maintenance. Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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