Thermo Fisher Scientific CRYAB Polyclonal Antibody

Applications

• Western Blot (WB): 1:5,000–1:50,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (97%), Rat (96%), Rabbit (97%), Chicken (81%), Sheep (96%), Rhesus Monkey (99%), Bovine (97%), Guinea pig (97%).
• Positive control: Mouse eye.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest and composed of two primary gene products, alpha-A and alpha-B.
Alpha-Crystallin comprises about 40% of total lens protein composition and functions as a molecular chaperone, preventing protein aggregation that may lead to cataract formation.
Phosphorylated states of alpha-crystallin may respond to cellular stress and play a role in structural control and protein maintenance. Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.