Thermo Fisher Scientific SOD2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SOD2, validated for WB and IHC(P). Recognizes multiple species with high predicted reactivity. Suitable for detecting mitochondrial Mn-SOD involved in oxidative stress defense. Supplied as liquid, antigen affi...
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | — |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | — |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Baboon, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human SOD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.42 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792327 |
Product Specific Information
- Keep as a concentrated solution.
- Predicted reactivity: Mouse (92%), Rat (94%), Zebrafish (88%), Xenopus laevis (86%), Pig (94%), Chicken (91%), Sheep (94%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (94%).
- Positive control: U87-MG, SK-N-SH, IMR32, SK-N-AS.
- Centrifuge briefly prior to opening the vial.
Target Information
Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). It catalyzes the dismutation of superoxide radical anion (O₂⁻) to hydrogen peroxide (H₂O₂), which is subsequently converted to water and oxygen by glutathione peroxidase and catalase.
There are several classes of SOD:
- SOD1 (Cu, Zn-SOD): Intracellular, homodimeric enzyme (32 kDa), present in all eukaryotic species.
- SOD2 (Mn-SOD): Mitochondrial enzyme (80 kDa tetramer), localized in the mitochondrial matrix near the respiratory chain.
- SOD3 (EC-SOD): Extracellular, heparin-binding multimer, mainly expressed in human lungs, vessel walls, and airways.
- SOD4 (CCS): Copper chaperone for SOD1, delivering Cu ions for activation.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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