Thermo Fisher Scientific COL1A2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:10,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (90%), Rat (89%), Dog (95%), Pig (95%), Rabbit (95%), Chicken (82%), Rhesus Monkey (100%), Bovine (93%).
• Positive Control: COL1A2-transfected 293T.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes the pro-alpha2 chain of type I collagen, which forms a triple helix composed of two alpha1 chains and one alpha2 chain. Type I collagen is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in this gene are associated with osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome.
Symptoms associated with mutations in this gene tend to be less severe than those in COL1A1, reflecting the different role of alpha2 chains in matrix integrity.
Three transcripts resulting from alternate polyadenylation signals have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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