Thermo Fisher Scientific Phospho-BCL-XL (Ser62) Polyclonal Antibody
Phospho-BCL-XL (Ser62)에 특이적인 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에서 사용 가능. Western blot, IHC, ICC/IF에 적합하며, Ser62 인산화된 BCL-XL만 검출. 고순도 정제 및 안정적 PBS/glycerol buffer 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2L1 (Accession Q07817), corresponding to amino acid residues around phosphorylated Ser62 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816448 |
Product Specific Information
Antibody detects endogenous levels of BCL-XL only when phosphorylated at Serine 62.
Target Information
BCL-XL is a member of the BCL-2 protein family, which forms hetero- or homodimers acting as anti- or pro-apoptotic regulators involved in various cellular activities. Located at the outer mitochondrial membrane, BCL-XL regulates VDAC channel opening, mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release—key factors in apoptosis. Two alternatively spliced transcript variants encode distinct isoforms: the longer isoform acts as an apoptotic inhibitor, while the shorter form acts as an activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 정보: PA5-104975_BCL-XL_Q07817-1_Rabbit.svg, PA5-104975_BCL-XL_Q07817-1_Rabbit_PDP.jpeg)
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