Thermo Fisher Scientific Phospho-Bcl-xL (Thr47) Polyclonal Antibody
BCL-XL 단백질의 Thr47 위치에서 인산화된 형태를 특이적으로 검출하는 폴리클로날 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 인간, 생쥐, 랫트 시료에 반응합니다. 고순도 정제된 액상 형태로 제공되며 -20°C에서 보관합니다.
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Thermo Fisher Scientific Phospho-Bcl-xL (Thr47) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2L1 (Accession Q07817), corresponding to amino acid residues around phosphorylated Thr47 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816447 |
Product Specific Information
This antibody detects endogenous levels of BCL-XL only when phosphorylated at Threonine 47.
Target Information
BCL-XL is a member of the BCL-2 protein family, which forms hetero- or homodimers acting as anti- or pro-apoptotic regulators involved in various cellular activities.
Located at the outer mitochondrial membrane, BCL-XL regulates VDAC channel opening, influencing mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release—key triggers of apoptosis.
Two alternatively spliced transcript variants encode distinct isoforms: the longer isoform inhibits apoptosis, while the shorter promotes it.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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