Thermo Fisher Scientific Phospho-p53 (Ser392) Polyclonal Antibody
p53 단백질의 Ser392 인산화를 특이적으로 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC(P), IP 등 다양한 응용에 사용 가능하며 Human, Mouse, Rat 시료에 반응합니다. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공합니다.
- 카탈로그번호
- 44640G
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from a region of mouse p53 containing serine 389 (conserved in rat). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | Dulbecco’s PBS (pH 7.3) with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533707 |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 upregulates genes such as p21waf1, contributing to G1 or G2/M arrest.
Structurally, p53 includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerization domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is crucial for p53 activation and stabilization, while phosphorylation at Ser392 is associated with human tumor formation. p53 also plays roles in aging, oxidative stress, and neuronal function. Normally expressed at low levels, p53 is overexpressed in many transformed cell lines, contributing to malignancy. Mutations in the TP53 gene can lead to loss of tumor suppressor activity and are implicated in various human cancers, including those seen in Li-Fraumeni syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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