Thermo Fisher Scientific ASK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ASK1 (MAP3K5). Suitable for Western blot applications. Recognizes residues 1356–1375 of ASK1. Recommended positive control: SW1353 cell lysate. For research use only.
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Thermo Fisher Scientific ASK1 Polyclonal Antibody
Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 1356–1375 of human ASK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070495 |
Product Specific Information
A suggested positive control for this product is SW1353 whole cell lysate.
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated in response to extracellular stimuli such as cytokines, growth factors, and environmental stress. ASK1 activates MAPKKs MKK4 and MKK6, which subsequently activate JNK and p38 MAP kinases. ASK1/MAPKKK5 is activated by TNFR and Fas through interaction with TRAF family members and Daxx. Overexpression of ASK1 induces apoptosis, while catalytically inactive ASK1 inhibits TNF-α-induced apoptosis. ASK1 is expressed in various human and mouse tissues.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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