Thermo Fisher Scientific Glutamine Synthetase Polyclonal Antibody
Thermo Fisher의 Glutamine Synthetase Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 WB, IHC, ICC, ELISA에 사용 가능합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적이며 -20°C 보관이 권장됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–373 of human Glutamine Synthetase (GLUL) (NP_0020562) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.44 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914487 |
Product Specific Information
Positive test controls include: 293T, Mouse brain, Rat brain.
The target is usually found in the following locations: Cytoplasm, Mitochondrion.
Immunogen sequence:
MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS VTEALIRTCL LNETGDEPFQ YKN
Target Information
Glutamine synthetase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthetase. Glutamate plays a central role in mammalian nitrogen flow, serving as both a nitrogen donor and acceptor. It also regulates neurotransmitter glutamate metabolism. Due to its multiple functions and importance in cellular metabolism, GS activity and synthesis are highly regulated, primarily controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer’s disease and under conditions of glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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