Thermo Fisher Scientific IRAK-M Polyclonal Antibody
IRAK-M 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 3.39 mg/mL 농도의 액상 형태로 제공됩니다. Affinity Chromatography로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 367–596 of human IRAK3 (NP_009130.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.39 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914491 |
Product Specific Information
- Positive test controls: THP-1, NCI-H125, Rat liver
- Immunogen sequence:
VLTGCRVVLD DPKHIQLRDL LRELMEKRGL DSCLSFLDKK VPPCPRNFSA KLFCLAGRCA ATRAKLRPSM DEVLNTLEST QASLYFAEDP PTSLKSFRCP SPLFLENVPS IPVEDDESQN NNLLPSDEGL RIDRMTQKTP FECSQSEVMF LSLDKKPESK RNEEACNMPS SSCEESWFPK YIVPSQDLRP YKVNIDPSSE APGHSCRSRP VESSCSSKFS WDEYEQYKKE
Target Information
IRAK3 (Interleukin-1 receptor-associated kinase 3) is a serine/threonine kinase and a member of the IRAK protein family, which are essential components of the Toll/IL-1 receptor immune signaling pathways. It is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 plays a critical role in innate immunity and is implicated in immunocompromised conditions during sepsis. Mutations in IRAK3 are associated with susceptibility to asthma.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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