Thermo Fisher Scientific Fibronectin Monoclonal Antibody (SPM539)
Thermo Fisher Scientific의 Fibronectin Monoclonal Antibody (SPM539)는 인간 fibronectin을 인식하는 Mouse IgG1 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. 고순도 Protein A/G 정제, PBS buffer, 무보존제, 연구용으로만 사용됩니다.
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- 2335MSM1XP1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM539 |
| Immunogen | Human fibronectin purified from serum by affinity chromatography on gelatin-sepharose |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling, and also present at high concentrations as a soluble plasma protein.
Fibronectin consists of repeating modules forming domains for interaction with fibronectin itself, other matrix components (e.g., collagen and heparin), and cell receptors (e.g., integrins). It plays crucial roles in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Elevated fibronectin expression is associated with non-small cell lung carcinoma, enhancing tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents. The gene encoding fibronectin has three regions subject to alternative splicing, potentially producing up to 20 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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