Thermo Fisher Scientific Fibronectin Monoclonal Antibody (Fn-3)
인간 Fibronectin을 인식하는 Mouse IgG1 단일클론 항체로, IHC, ICC/IF, Flow Cytometry에 사용 가능. Protein A/G로 정제된 액상형 항체이며, PBS buffer에 보관. 세포 부착 및 이동 연구, 암 관련 기전 분석에 적합.
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Applications
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–2 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1–2 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Fn-3 |
| Immunogen | FR5 cells, derived by SV40 transformation of human mammary epithelial cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In connective tissues and vessels, it exists as an insoluble, cross-linked polymer. It is abundant during embryonic development and tissue remodeling, and also found as a soluble plasma protein. Fibronectin mediates interactions with collagen, heparin, and cell surface receptors such as integrins. It plays key roles in cell adhesion, migration, wound healing, coagulation, host defense, and metastasis. Elevated Fibronectin expression is associated with non-small cell lung carcinoma and contributes to tumorigenicity and resistance to apoptosis. The gene has three alternatively spliced regions, potentially generating up to 20 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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