Thermo Fisher Scientific Fibronectin (Cellular and Plasma) Monoclonal Antibody (TV-1)

Applications and Tested Dilution

Product Specifications

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also present at high concentrations as a soluble plasma protein.

Fibronectin consists of repeating modules forming domains for interaction with fibronectin itself, other matrix components (e.g., collagen and heparin), and receptors on cells (e.g., integrins). It plays a key role in cell adhesion and migration processes, including embryogenesis, wound healing, blood coagulation, host defense, and metastasis.

Fibronectin expression is increased in non-small cell lung carcinoma, where its adhesion enhances tumorigenicity and confers resistance to apoptosis induced by chemotherapeutic agents. The gene encoding fibronectin has three regions subject to alternative splicing, potentially producing up to 20 transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.