Thermo Fisher Scientific ATF6 Polyclonal Antibody
인간 ATF6 단백질을 표적으로 하는 Thermo Fisher Scientific의 다클론 항체로, WB, IHC, ICC, ELISA 등 다양한 실험에 사용 가능. 친화 크로마토그래피로 정제된 액상 형태이며, 안정적인 저장 조건 제공. ER 스트레스 관련 단백질 연구에 적합.
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Thermo Fisher Scientific ATF6 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunohistochemistry (IHC) | 1:200 |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 5.0 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-ATF6 antibody prepared from whole rabbit serum immunized with a synthetic peptide corresponding to the N-terminal portion of human ATF6 conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This affinity-purified antibody is directed against human ATF6. Blast analysis of the immunogen sequence shows 100% identity with human and 80% identity with rat.
Target Information
ATF6 is a transcription factor involved in the endoplasmic reticulum (ER) stress response by activating unfolded protein response (UPR) target genes. It binds DNA at the ER stress response element (ERSE) and ERSE II sequences.
Binding to ERSE requires interaction with NF-Y. ATF6 forms homodimers and heterodimers with ATF6 beta and interacts with NF-YC, GTF2I, YY1, and SRF.
During ER stress, the cleaved N-terminal cytoplasmic domain translocates to the nucleus, functioning as a transcription factor. The basic domain serves as a nuclear localization signal, and the leucine-zipper domain facilitates NF-Y binding.
ATF6 is N-glycosylated, phosphorylated by MAPK14/P38MAPK, and belongs to the bZIP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 600-401-GU9_ATF6_P18850-1_Rabbit.svg, 600-401-GU9_ATF6_P18850-1_Rabbit_PDP.jpeg)
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