Thermo Fisher Scientific PINK1 truncated Polyclonal Antibody
인간 및 생쥐 PINK1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry, ELISA, IP에 사용 가능. Affinity chromatography로 정제되었으며, -20°C 보관 권장. 미토콘드리아 기능 연구 및 파킨슨병 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 1:200 |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a C-terminal portion of human PINK1 conjugated to Keyhole Limpet Hemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This affinity purified antibody is directed against human PINK1. Blast analysis of the immunogen sequence shows 100% identity with human and 93% identity to mouse.
Target Information
PINK1 (PTEN-induced putative kinase 1) protects cells from mitochondrial dysfunction by regulating autophosphorylation activity of mitochondrial genes. The kinase domain of PINK1 is critical for its protective effects. Mitochondrial proteins play key roles in cellular energy regulation and stress adaptation, particularly in brain cells where high energy demand exists. Disruption of mitochondrial structure or function in the brain can lead to neurodegenerative diseases such as Parkinson’s disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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