Thermo Fisher Scientific NPM1 Monoclonal Antibody (4TOU-1B2)

Applications 및 Tested Dilution

Product Specifications

Product Specific Information

MA3-086 detects Nucleophosmin from human and mouse samples.
It has been successfully used in Western blot, immunofluorescence, Flow Cytometry, and ELISA applications.

Target Information

NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly and transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53.
NPM1 shuttles between the nucleus, cytoplasm, and nucleolus, chaperoning core histones and preventing protein aggregation through its chaperon activities. It protects enzymes during thermal denaturation and facilitates renaturation of chemically denatured proteins.
NPM1 is associated with the centrosome and is a substrate of CDK2/cyclin E during centrosome duplication. It interacts with tumor-associated chromosome translocations forming fusion proteins such as NPM-ALK, NPM-RAR, and NPM-MLF1, acting as an interface for oligomerization and oncogenic conversion.
Additionally, NPM1 sequesters the tumor suppressor RF in the nucleolus, protecting it from degradation. Dysfunction of NPM1 is associated with diseases such as acute myeloid leukemia and lymphomatoid papulosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.