Thermo Fisher Scientific PITX2 Monoclonal Antibody (OTI1H10), TrueMAB
PITX2 단백질을 표적으로 하는 단클론 항체로, Western blot에 적합합니다. Human, Mouse, Rat에 반응하며 IgG1 아이소타입입니다. 동결건조 형태로 제공되며, 재구성 시 1 mg/mL 농도로 사용 가능합니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–200 of human PITX2 produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
PITX2 is a member of the RIEG/PITX homeobox family within the bicoid class of homeodomain proteins. It functions as a transcription factor regulating procollagen lysyl hydroxylase gene expression and contributes to terminal differentiation of somatotroph and lactotroph cell phenotypes.
This protein plays roles in the development of the eye, tooth, and abdominal organs, and in transcriptional regulation of prolactin activity.
Mutations are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and Peters anomaly. Homologous proteins in other species are involved in left-right asymmetry determination during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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