Thermo Fisher Scientific M-CSF Recombinant Rabbit Monoclonal Antibody (SU0413)
Recombinant rabbit monoclonal antibody targeting human M-CSF for WB, IHC, ICC/IF, and IP applications. Offers high specificity, lot-to-lot consistency, and animal origin-free formulation. Supplied as liquid form at 1 mg/mL, purified by Protein A, store...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SU0413 |
| Immunogen | Synthetic peptide within Human M-CSF (aa 56–105) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% Sodium Azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2809429 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
M-CSF (Macrophage Colony-Stimulating Factor, CSF-1) is essential for proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. It induces VEGF secretion by macrophages, promoting mobilization of endothelial progenitor cells and neovascularization.
M-CSF exists as multiple bioactive isoforms differing in potency and stability. The full-length protein is membrane-spanning and can be cleaved into secreted forms. It functions as a disulfide-bonded homodimer, forming glycoprotein or proteoglycan isoforms.
Binding of M-CSF to its receptor c-Fms (CSF-1R/CD115) triggers receptor dimerization, internalization, and degradation. Functionally, M-CSF stimulates differentiation of hematopoietic stem cells into monocyte-macrophage populations.
Human M-CSF shows activity on mouse cells, while mouse CSF is inactive on human cells.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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