Thermo Fisher Scientific Desmin Polyclonal Antibody
Rabbit polyclonal antibody targeting human desmin for muscle cell research. Validated for WB, IHC (P), and ICC/IF applications. Predicted cross-reactivity with mouse and rat. Ideal for skeletal muscle or sarcoma as positive control. Stored at 4°C, not ...
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Thermo Fisher Scientific Desmin Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Ready-to-use |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide mapping near the C-terminus of human desmin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_1074024 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
A suggested positive control is skeletal muscle or sarcoma.
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly expressed in all types of muscle cells (cardiac, skeletal, and smooth muscle).
Regulation of desmin expression is stage and tissue-specific, induced during terminal development of skeletal muscle cell differentiation.
In skeletal and cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk.
The expression pattern in smooth muscle is more heterogeneous.
Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, such as rhabdomyosarcomas and leiomyosarcomas.
During myocardial dysfunction, dramatic changes in desmin distribution have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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