Thermo Fisher Scientific BLVRA Monoclonal Antibody (4G4-2B6)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK

Target Information

Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, which converts heme to iron, carbon monoxide, and biliverdin.
BLVR is unique among enzymes in being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor.
There are two isoforms:

• BLVRA (biliverdin-IX alpha-reductase): Major component of human adult liver
• BLVRB (biliverdin-IX beta-reductase): Found predominantly in fetal liver

The product of BLVR, bilirubin, acts as a biological antioxidant but is also a neurotoxin and the cause of kernicterus. In addition to its antioxidant role, bilirubin inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.