Thermo Fisher Scientific CXCR5 Monoclonal Antibody (2C1)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.03 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVP

Target Information

CXCR5 (C-X-Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family.
CXCR5 is a G protein-coupled seven transmembrane receptor for chemokine BLC. The CXCR5 gene is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen.

Studies suggest CXCR5 plays an essential role in B cell migration. CXCR5 expression has been observed in human blood and salivary gland, and in animal lymphatic organs, blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil.

ESTs have been isolated from human brain, germ cell, lung, lymph, and pancreas.
G-protein Coupled Receptors (GPCRs) are one of the largest families of signaling molecules, sharing a seven membrane-spanning helix structure. They exist in active and inactive forms, and their regulation is crucial for cellular physiological functions.

GPCR-targeted pharmaceuticals include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), used in mental health and allergy treatments.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.