Thermo Fisher Scientific BLVRA Monoclonal Antibody (S1)
BLVRA 단백질을 인식하는 Thermo Fisher Scientific의 Mouse 단일클론 항체(S1)로, Western blot과 ELISA에 적합합니다. Human 반응성, 비결합형 액상 형태이며 -20°C 보관. Biliverdin Reductase 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S1 |
| Immunogen | BLVRA (AAH08456, 1–296 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK
Target Information
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin.
BLVR is dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor.
There are two isoforms:
- BLVRA: Major component of human adult liver
- BLVRB: Predominantly found in fetal liver
The product of BLVR, bilirubin, acts as an antioxidant but can also be neurotoxic and cause kernicterus. In addition, bilirubin inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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