Thermo Fisher Scientific BLVRA Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK

Target Information

Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, which converts heme to iron, carbon monoxide, and biliverdin.
BLVR is unique among all enzymes in being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor.
There are two isoforms of BLVR:

• BLVRA (biliverdin-IX alpha-reductase): major component of human adult liver
• BLVRB (biliverdin-IX beta-reductase): found predominantly in fetal liver

The product of BLVR, bilirubin, acts as a biological antioxidant but can also be a neurotoxin responsible for kernicterus. Additionally, it inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.