Thermo Fisher Scientific CXCR5 Polyclonal Antibody, MaxPab

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Protein sequence:

MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL SESENATSLT TF

Target Information

CXCR5 (C-X-Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family. It is a G protein-coupled seven-transmembrane receptor for chemokine BLC. CXCR5 is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen. It plays an essential role in B cell migration.

CXCR5 expression has been observed in human blood, salivary gland, and various animal tissues including lymphatic organs, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil. ESTs have been isolated from human brain, germ cell, lung, lymph, and pancreas.

G-protein Coupled Receptors (GPCRs) share a common seven-helix transmembrane structure and exist in both active and inactive forms. Ligand binding triggers G-protein signaling and downstream effects. GPCR regulation mechanisms are key to understanding cellular physiology and developing pharmacological agents. Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), used in mental health and allergy treatments, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.