Thermo Fisher Scientific DCC Monoclonal Antibody (OTI5D10), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes a netrin 1 receptor, a transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules. It mediates axon guidance of neuronal growth cones toward sources of netrin 1 ligand.
The cytoplasmic tail interacts with tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts and induces apoptosis in the absence of ligand.
DCC functions as a tumor suppressor and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.