Thermo Fisher Scientific VDR Recombinant Rabbit Monoclonal Antibody (JA11-16)
VDR 단백질 검출용 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공합니다. Western blot, IHC, Flow cytometry에 적합하며, HEK293 발현 시스템에서 생산되었습니다. 로트 간 일관성과 동물 유래 성분이 없는 포뮬레이션을 제공합니다.
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Thermo Fisher Scientific VDR Recombinant Rabbit Monoclonal Antibody (JA11-16)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA11-16 |
| Immunogen | Synthetic peptide corresponding to Human Vitamin D Receptor (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809933 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to large rabbit immune repertoire
Target Information
Steroid receptors are ligand-dependent intracellular proteins that regulate transcription of specific genes. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the steroid hormone receptor superfamily, which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors.
Vitamin D influences calcium and phosphorus homeostasis, bone remodeling, cell growth, and differentiation. VDR is expressed in the intestine, bone, kidney, epidermis, and endocrine immune cells. VDR binding within the IL-2 enhancer represses T-cell proliferation and IL-2 gene expression. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)₂D₃ interferes with NFATp/Fos/Jun/DNA complex assembly and subsequent IL-2 transcription.
The corresponding gene for the vitamin D receptor is NR1I1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: MA5-32656_VDR_P11473-1_Rabbit.svg, MA5-32656_VDR_P11473-1_Rabbit_PDP.jpeg)
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