Thermo Fisher Scientific MINA53 Recombinant Rabbit Monoclonal Antibody (JA11-63)
MINA53 단백질을 타겟으로 한 재조합 토끼 단클론 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현되었습니다. 단백질 A 정제, 액상 형태로 제공되며, 장기 보관 시 -20°C에서 안정적입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA11-63 |
| Immunogen | Synthetic peptide within Human MINA53 aa 416–465 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809932 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed in HEK293 cells. Each clone is screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to rabbit immune repertoire
Target Information
MINA is a nuclear-localized, myc-inducible protein involved in mammalian cell proliferation. Knockdown of MINA in cancer cell lines such as SW680 inhibits growth, suggesting its potential as a therapeutic target.
It regulates genes associated with cell adhesion and metabolism, some of which overlap with c-Myc targets (e.g., EGFR, IL-6, HGF).
Additionally, MINA represses IL-4 expression in T cells, indicating a role in T cell differentiation and Th2 bias regulation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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