Thermo Fisher Scientific DCLK1 Recombinant Rabbit Monoclonal Antibody (JA11-03)
DCLK1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공합니다. Western blot 및 IHC(Paraffin)에서 검증되었으며, HEK293 발현 시스템을 사용하여 생산되었습니다. 로트 간 일관성과 동물 유래 성분이 없는 포뮬레이션을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA11-03 |
| Immunogen | Synthetic peptide within Human DCAMKL1 aa 649–698 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2809934 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal production candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to rabbit immune repertoire
Target Information
DCAMKL1 (DCLK1, doublecortin-like kinase 1) is a serine/threonine kinase containing two N-terminal doublecortin domains that bind microtubules and regulate their polymerization. It also includes a C-terminal kinase domain homologous to Ca²⁺/calmodulin-dependent protein kinase, and a serine/proline-rich domain mediating protein-protein interactions.
DCAMKL1 is a microtubule-associated kinase capable of autophosphorylation and exhibits microtubule-polymerizing activity independent of its kinase function. It participates in neuronal migration, retrograde transport, apoptosis, and neurogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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